More than one million lives have been lost since the start of the opioid epidemic. Overdoses and deaths involving synthetic opioids have reached record rates, and every community across our nation is feeling the impact. Rx and Illicit Drug Summit is the largest, most influential event addressing this crisis, where strategies are shared and put into action. Our global community includes multidisciplinary stakeholders "from federal to family." As we enter our 14th year, our mission has become increasingly important—we can't afford to lose more lives. It's time to turn the numbers around.